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Genes and Chromosomes

The living organisms divide into two major groups: prokaryotes, which are single-celled organisms with no cell nucleus, and eukaryotes, which are higher level organisms, and their cells have nuclei.

Eukariotic cell nuclei contain chromosomes - the contiguous structures in which DNA is stored. Every cell usually includes two copies of each chromosome (excluding, in males, the sex X,Y chromosomes). Sex cells include only one copy of each chromosome. The number of chromosomes varies among species. Humans have 22 pairs of chromosomes, plus the pair of sex chromosomes. In humans, the size of the chromosomes varies between \(
3\times 10^{7} - 3\times 10^{8} \)bp.

With contemporary knowledge of the biochemical basis of heredity, Mendel's abstract concept of a gene can be redefined as a physical entity, in terms of actual matter. A gene is a specific sequence of nucleotide bases along a chromosome, and most of the times it carries information for constructing a protein. Genes are parts of the chromosomes. In humans genes constitute approximately \( 5-10\% \) of the DNA, leaving \( 90-95\% \)of nongenic "junk DNA". The role of the latter is as yet unknown, but it is speculated to be very important. Several theories have been suggested, such as physically fixing the DNA in its compressed position, preserving old genetic data, etc. The total number of genes in humans is estimated to be between 30,000 and 80,000.


next up previous
Next: RNA and Transcription Up: Genetic information Previous: DNA replication
Peer Itsik
2000-11-13