Chooser Evaluation

In order to evaluate chooser performance the following simulation was performed: A network with 20 nodes, 24 edges and maximum in-degree 4 was generated. The expression matrix E consisted of the wild-type and all single perturbations. Next, 8 parsimonious networks were inferred, all with 21 edges, which were consistent with E. The chooser was used to select a double perturbation which had maximal entropy score over the 8 networks, and the process was repeated iteratively until only a single network was inferred. The results are summarized in the figure 14.20. They show a pattern of jumps and decays in the number of network solutions, correlated with an increase of number of inferred edges.

  

Figure 14.20: Summary of chooser evaluation: progress through experimental design