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Distance between DNA Sequences - Jukes-Cantor Model
According to the model of Jukes and Cantor [8] each base in the DNA
sequence has an equal chance of mutating, and when it does, it is replaced by some
other nucleotide uniformly. For a mutation probability of
during each infinitesimally small period of time ,
the chance of a
nucleotide x remaining unchanged over a period of T time units is (recall
exercise #1):
Given a branch in the tree, the probability that the site is different at the two
edges is therefore:
The Jukes-Cantor model defines an additive distance by using the difference per
site to estimate
itself. The values of
on each
branch will, by definition, add perfectly.
Itshack Pe`er
1999-02-18